The Briegel lab is part of the Institute of Biology at the Leiden University and the Centre of Microbial Cell Biology. We are interested in understanding how microbes sense and respond to their environment.

How are the cells able to actively seek out their preferred environmental niches, how can they effectively evade toxins and predators, and how can they adapt to thrive in changing environments

In order to gain insight into the structure and function of the molecular complexes involved in these behaviors, we use cryo-electron tomography (cryo-ET). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

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